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Naltrexone is eligible to treat alcohol and opioid dependence. Bupropion is approved to treat depression and seasonal affective disorder and as an aid to smoking cessation treatment.'Obesity may be a major public health concern,' said Jean-Marc Guettier, M.D., director from the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination with a healthy lifestyle that includes a reduced-calorie eating and working out, Contrave provides another treatment choice for chronic weight loss for people who are obese or are overweight and have at least one weight-related health problem.'The drug's effectiveness was evaluated in multiple numerous studies that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated for just one year. All patients received lifestyle modification that contains a reduced- calorie diet and regular exercising. Results from a clinical trial that enrolled patients without diabetes indicated that patients had the average weight loss of 4.1% in contrast to participants have been given placebos) throughout a 12- month period, while an outside study involving patients with diabetes had a typical weight loss of 2% over treatment with placebo at one full year. Using two separate drugs to lose weight can be very effective you'll find combinations while watching FDA now awaiting approval. When dealing with weight-loss and the those who go through it one should err on the side of caution and permit the FDA do its job and demand some study be done so your public is aware of the side effects and dangers of the medications before we bring them. Keep in mind that drug companies are in business to make money and that they would say anything to keep people on their own medications. Researchers found out that participants taking this drug to get a year, dropped a few pounds within 4 weeks and have kept the extra weight off through the 56 weeks of the study. Contrave is a combination in the drugs naltrexone and bupropion, which appears to reflect a new trend of weight-loss drugs which are made up of several active ingredient, which can make them more potent and safer. Combo-pilling may be the newest fad or better yet the newest ahead under scrutiny and so it is just more publicly known in recent months, comb-pilling for weight reduction has been around since the eighties. The biggest reason that utilizing a combination of pills is now popular could be the fact that since right now there aren't long term prescription diet pills that have been approved by the FDA aside from orlistat. The truly disturbing part is always that doctors are prescribing these combinations of medications although some people might of the combinations happen to be rejected or have yet to be authorized by the FDA. Seizures certainly are a side effect with Contrave and shouldn't be taken in individuals with seizure disorders. The drug may also raise blood pressure and pulse rate, and mustn't be used in individuals with a history of cardiac event or stroke in the earlier six months. Blood pressure and pulse should also be measured before commencing the drug and throughout therapy while using drug. The FDA also warned that Contrave can raise blood pressure levels and heartrate and must not used in patients with uncontrolled high blood pressure, in addition to by anyone with heart-related and cerebrovascular (circulation system dysfunction impacting your brain) disease. Patients having a history of cardiac event or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded from the clinical trials. Those taking Contrave needs to have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes with a boxed warning to alert medical professionals and patients on the increased risk of suicidal thoughts and behaviors associated with antidepressant drugs. The warning also notes that serious neuropsychiatric events are actually reported in patients taking bupropion for stopping smoking. &#13;To keep up with essentially the most current articles from Wendi, the Indiana Addiction Recovery Examiner, click on the subscribe link near the top of the page to obtain email notification when new content is published. Please leave a comment for almost any article.