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Contrave is a combination of the drugs naltrexone and bupropion, which generally seems to reflect a brand new trend of weight-loss drugs which are made up of several active ingredient, that might make them more effective and safer. Combo-pilling is the newest fad or even better the newest ahead under scrutiny and thus it is just more publicly known although in the past, comb-pilling for weight loss has been around since the eighties. The biggest reason that employing a combination of pills has become popular is the fact that by right now there are no long term prescription weightloss pills that have been licensed by the FDA other than orlistat. The truly disturbing part is that doctors are prescribing these combinations of medications and some of the combinations happen to be rejected or have yet to be licensed by the FDA. Seizures are a side effect with Contrave and really should not be taken in individuals with seizure disorders. 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