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Combo-pilling could be the newest fad or also the newest in the future under scrutiny and therefore it is just more publicly known lately, comb-pilling for weight loss has been around since the eighties. The biggest reason that using a combination of pills is becoming popular will be the fact that since right now there are not any long term prescription weight loss supplements that have been licensed by the FDA aside from orlistat. The truly disturbing part is doctors are prescribing these combinations of medications even though some of the combinations are actually rejected or have yet to be authorized by the FDA. Seizures are a side effect with Contrave and must not be taken in individuals with seizure disorders. The drug could also raise blood pressure levels and pulse rate, and must not be used in people who have a history of heart attack or stroke in the earlier six months. 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